Wilen Lab

We use CRISPR screens, mouse models, and molecular biology to discover how viruses interact with other microbes and the host to cause disease.

About the Lab

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The Wilen lab is located at the Yale School of Medicine in the Departments of Laboratory Medicine and Immunobiology. We are interested in how viruses, particularly norovirus, interact with and evade the immune system.

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Craig B. Wilen,
MD, PhD

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Assistant Professor of Laboratory Medicine and Immunobiology

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Dr. Wilen received his A.B in Biology and Economics at Washington University in St. Louis, his MD and PhD from the University of Pennsylvania. His residency training was in clinical pathology at Barnes-Jewish Hospital in St. Louis, MO. His postdoctoral studies were conducted in the laboratory of Herbert "Skip" Virgin in the Department of Pathology & Immunology at Washington University School of Medicine where he studied the pathogenesis of norovirus, the leading cause of acute gastroenteritis globally.

Projects

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Norovirus Pathogenesis - Human norovirus causes a gastrointestinal illness characterized by profuse diarrhea and vomiting.

Viral Immune Evasion - Evolutionarily successful viruses must overcome the host innate and adaptive immune responses.

Type II immunity and Viral infection - Intestinal worms and parasites elicit a type II immune response characterized by production of the cytokines IL4-, IL-5, and IL-13 which facilitate clearance of the worms and parasites.

Tuft cell biology - Tuft cells are named after their long tuft of microvilli that protrudes into the intestinal lumen.

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Norovirus Pathogenesis

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Tuft Cell Biology

14pi colon CR6 SL paper outset

Viral Immune Evasion

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Type II Immunity and Viral Infection