Selected publications

2024

Intestinal tuft cell immune privilege enables norovirus persistence.

Strine MS, Fagerberg E, Darcy PW, Barrón GM, Filler RB, Alfajaro MM, D'Angelo-Gavrish N, Wang F, Graziano VR, Menasché BL, Damo M, Wang YT, Howitt MR, Lee S, Joshi NS, Mucida D, Wilen CB. Science Immunology. 2024 Mar 22;9(93):eadi7038. doi: 10.1126/sciimmunol.adi7038. Epub 2024 Mar 22.PMID: 38517952

SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity.

Peña-Hernández MA, Alfajaro MM, Filler RB, Moriyama M, Keeler EL, Ranglin ZE, Kong Y, Mao T, Menasche BL, Mankowski MC, Zhao Z, Vogels CBF, Hahn AM, Kalinich CC, Zhang S, Huston N, Wan H, Araujo-Tavares R, Lindenbach BD, Homer R, Pyle AM, Martinez DR, Grubaugh ND, Israelow B, Iwasaki A, Wilen CB. Nature Microbiology 2024 Aug;9(8):2038-2050. doi: 10.1038/s41564-024-01765-z. Epub 2024 Jul 29.PMID: 39075235

A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection.

Mayer DP, Nelson ME, Andriyanova D, Filler RB, Ökten A, Antao OQ, Chen JS, Scumpia PO, Weaver WM, Wilen CB, Deshayes S, Weinstein JS.J Control Release. 2024 Jun;370:570-582. doi: 10.1016/j.jconrel.2024.05.008. Epub 2024 May 11.PMID: 38734312 

Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract.

Mao T, Kim J, Peña-Hernández MA, Valle G, Moriyama M, Luyten S, Ott IM, Gomez-Calvo ML, Gehlhausen JR, Bak, Deshayes S, Weinstein JS. J Control Release. 2024 Jun;370:570-582. doi: 10.1016/j.jconrel.2024.05.008. Epub 2024 May 11.PMID: 38734312 urveillance Initiative; Gopinath S, Wilen CB, Palm N, Dela Cruz CS, Iwasaki A.  Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2319566121. doi: 10.1073/pnas.2319566121. Epub 2024 Apr 22.PMID: 38648490

Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB-dependent IFITM3 expression.

Munir M, Embry A, Doench JG, Heaton NS, Wilen CB, Orchard RC.J Biol Chem. 2024 Apr;300(4):107153. doi: 10.1016/j.jbc.2024.107153. Epub 2024 Mar 9.PMID: 38462163 

Human iPSC-Based Model of COPD to Investigate Disease Mechanisms, Predict SARS-COV-2 Outcome, and Test Preventive Immunotherapy.

Dagher R, Moldobaeva A, Gubbins E, Clark S, Madel Alfajaro M, Wilen CB, Hawkins F, Qu X, Chien Chiang C, Li Y, Clarke L, Ikeda Y, Brown C, Kolbeck R, Ma Q, Rojas M, Koff JL, Ghaedi M. Stem Cells. 2024 Mar 14;42(3):230-250. doi: 10.1093/stmcls/sxad094.PMID: 38183264

2023

Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53.

Lee JD, Menasche BL, Mavrikaki M, Uyemura MM, Hong SM, Kozlova N, Wei J, Alfajaro MM, Filler RB, Müller A, Saxena T, Posey RR, Cheung P, Muranen T, Heng YJ, Paulo JA, Wilen CB, Slack FJ. Cell Reports. 2023 Dec 26;42(12):113478. doi: 10.1016/j.celrep.2023.113478. Epub 2023 Nov 21.PMID: 37991919

IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus.

Ingle H, Makimaa H, Aggarwal S, Deng H, Foster L, Li Y, Kennedy EA, Peterson ST, Wilen CB, Lee S, Suthar MS, Baldridge MT. Sci Adv. 2023 Sep 15;9(37):eadi2562. doi: 10.1126/sciadv.adi2562. Epub 2023 Sep 13.PMID: 37703370

Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer.

de Miguel FJ, Gentile C, Feng WW, Silva SJ, Sankar A, Exposito F, Cai WL, Melnick MA, Robles-Oteiza C, Hinkley MM, Tsai JA, Hartley AV, Wei J, Wurtz A, Li F, Toki MI, Rimm DL, Homer R, Wilen CB, Xiao AZ, Qi J, Yan Q, Nguyen DX, Jänne PA, Kadoch C, Politi KA.Cancer Cell. 2023 Aug 14;41(8):1516-1534.e9. doi: 10.1016/j.ccell.2023.07.005. Epub 2023 Aug 3.PMID: 37541244 

Murine Norovirus: Additional Protocols for Basic and Antiviral Studies.

Wobus CE, Peiper AM, McSweeney AM, Young VL, Chaika M, Lane MS, Lingemann M, Deerain JM, Strine MS, Alfajaro MM, Helm EW, Karst SM, Mackenzie JM, Taube S, Ward VK, Wilen CB. Current Protocols. 2023 Jul;3(7):e828. doi: 10.1002/cpz1.828.PMID: 37478303 

The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.

Wei J, Alfajaro MM, Cai WL, Graziano VR, Strine MS, Filler RB, Biering SB, Sarnik SA, Patel S, Menasche BL, Compton SR, Konermann S, Hsu PD, Orchard RC, Yan Q, Wilen CB. PLoS Pathogens 2023 Jul PMID: 37410700

PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.

Xu D, Jiang W, Wu L, Gaudet RG, Park ES, Su M, Cheppali SK, Cheemarla NR, Kumar P, Uchil PD, Grover JR, Foxman EF, Brown CM, Stansfeld PJ, Bewersdorf J, Mothes W, Karatekin E, Wilen CB, MacMicking JD.Nature. 2023 Jul;619(7971):819-827. doi: 10.1038/s41586-023-06322-y. Epub 2023 Jul 12.PMID: 37438530 

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner. Strine MS, Cai WL, Wei J, Alfajaro MM, Filler RB, Biering SB, Sarnik S, Chow RD, Patil A, Cervantes KS, Collings CK, DeWeirdt PC, Hanna RE, Schofield K, Hulme C, Konermann S, Doench JG, Hsu PD, Kadoch C, Yan Q, Wilen CB. PLoS Biology 2023 Jun PMID: 37310920 

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.Wei J, Patil A, Collings CK, Alfajaro MM, Liang Y, Cai WL, Strine MS, Filler RB, DeWeirdt PC, Hanna RE, Menasche BL, Ökten A, Peña-Hernández MA, Klein J, McNamara A, Rosales R, McGovern BL, Luis Rodriguez M, García-Sastre A, White KM, Qin Y, Doench JG, Yan Q, Iwasaki A, Zwaka TP, Qi J, Kadoch C, Wilen CB. Nature Genetics. 2023 Mar PMID: 36894709 

Systematic detection of tertiary structural modules in large RNAs and RNP interfaces by Tb-seq.

Patel S, Sexton AN, Strine MS, Wilen CB, Simon MD, Pyle AM. Nature Communications. 2023 Jun PMID: 37296103 

Game over for RSV?

Strine MS, Wilen CB. Science Immunology 2023 Jun 2.PMID: 37276355

Age-associated features of norovirus infection analysed in mice.

Kennedy EA, Aggarwal S, Dhar A, Karst SM, Wilen CB, Baldridge MT. Nature Microbiology 2023 PMID: 37188813

Nonsystematic Reporting Biases of the SARS-CoV-2 Variant Mu Could Impact Our Understanding of the Epidemiological Dynamics of Emerging Variants.

Petrone ME, Lucas C, Menasche B, Breban MI, Yildirim I, Campbell M, Omer SB, Holmes EC, Ko AI, Grubaugh ND, Iwasaki A, Wilen CB, Vogels CBF, Fauver JR. Genome Biol Evol. 2023 Apr PMID: 36974986 

2022

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity.

Strine MS, Alfajaro MM, Graziano VR, Song J, Hsieh LL, Hill R, Guo J, VanDussen KL, Orchard RC, Baldridge MT, Lee S, Wilen CB. Cell Reports. 2022 Nov PMID: 36351394 

LRRC15 inhibits SARS-CoV-2 cellular entry in trans.

Song J, Chow RD, Peña-Hernández MA, Zhang L, Loeb SA, So EY, Liang OD, Ren P, Chen S, *Wilen CB, *Lee S. PLoS Biology. 2022 Oct PMID: 36228039

Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein.

Lapidus S, Liu F, Casanovas-Massana A, Dai Y, Huck JD, Lucas C, Klein J, Filler RB, Strine MS, Sy M, Deme AB, Badiane AS, Dieye B, Ndiaye IM, Diedhiou Y, Mbaye AM, Diagne CT, Vigan-Womas I, Mbengue A, Sadio BD, Diagne MM, Moore AJ, Mangou K, Diallo F, Sene SD, Pouye MN, Faye R, Diouf B, Nery N Jr, Costa F, Reis MG, Muenker MC, Hodson DZ, Mbarga Y, Katz BZ, Andrews JR, Campbell M, Srivathsan A, Kamath K, Baum-Jones E, Faye O, Sall AA, Vélez JCQ, Cappello M, Wilson M, Ben-Mamoun C, Tedder R, McClure M, Cherepanov P, Somé FA, Dabiré RK, Moukoko CEE, Ouédraogo JB, Boum Y 2nd, Shon J, Ndiaye D, Wisnewski A, Parikh S, Iwasaki A, Wilen CB, Ko AI, Ring AM, Bei AK. Scientific Reports. 2022 Dec PMID: 36550362 

Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.

Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S,, Chen S. Cell Rep. 2022 Aug PMID: 35921835 ian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. Journal of  Immunology . 2022 Oct PMID: 36165196

Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species.

Peng L, Fang Z, Renauer PA, McNamara A, Park JJ, Lin Q, Zhou X, Dong MB, Zhu B, Zhao H, Wilen CB, Chen S. Cell Repo.rts 2022 Aug PMID: 35921835 

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. Nature Genetics. 2022 AugPMID: 35879412 

Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2.

Fang Z, Peng L, Lucas C, Lin Q, Zhou L, Yang L, Feng Y, Ren P, Renauer PA, Monteiro VS, Hahn AM, Park JJ, Zhou X; Yale SARS-CoV-2 Genomic Surveillance Initiative; Grubaugh ND, Wilen CB, Chen S.Cell Discov. 2022 Jul 19;8(1):69. doi: 10.1038/s41421-022-00435-w.PMID: 35853867

Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency.

Shin JJ, Par-Young J, Unlu S, McNamara A, Park HJ, Shin MS, Gee RJ, Doyle H, Afinogenova Y, Zidan E, Kwah J, Russo A, Mamula M, Hsu FI, Catanzaro J, Racke M, Bucala R, Wilen C, Kang I.J Clin Immunol. 2022 Aug PMID: 35713752 

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2.

Fang Z, Peng L, Filler R, Suzuki K, McNamara A, Lin Q, Renauer PA, Yang L, Menasche B, Sanchez A, Ren P, Xiong Q, Strine M, Clark P, Lin C, Ko AI, Grubaugh ND, Wilen CB, Chen S. Nature Communications. 2022 Jun PMID: 35668119

Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2.

Peng L, Renauer PA, Ökten A, Fang Z, Park JJ, Zhou X, Lin Q, Dong MB, Filler R, Xiong Q, Clark P, Lin C, Wilen CB, Chen S. Cell Reports Medicine. 2022 May PMID: 35561673 

Inflammasome activation in infected macrophages drives COVID-19 pathology.

Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Nature. 2022 Jun PMID: 35483404

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.

Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S. Nature Communications 2022 Mar PMID: 35347138 

De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report.

Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA Jr, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. Nature Communications. 2022 MarPMID: 35301314 

Tuft cells are key mediators of interkingdom interactions at mucosal barrier surfaces.

Strine MS, Wilen CB.PLoS Pathog. 2022 Mar 10;18(3):e1010318. doi: 10.1371/journal.ppat.1010318. eCollection 2022 Mar.PMID: 35271673 

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis.

Ortega-Gonzalez P, Taylor G, Jangra RK, Tenorio R, Fernandez de Castro I, Mainou BA, Orchard RC, Wilen CB, Brigleb PH, Sojati J, Chandran K, Sachse M, Risco C, Dermody TS.PLoS Pathog. 2022 Mar 9;18(3):e1010322. doi: 10.1371/journal.ppat.1010322. eCollection 2022 Mar.PMID: 35263388 

Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice.

Sharon AJ, Filyk HA, Fonseca NM, Simister RL, Filler RB, Yuen W, Hardman BK, Robinson HG, Seo JH, Rocha-Pereira J, Welch I, Neyts J, Wilen CB, Crowe SA, Osborne LC.J Virol. 2022 Mar 23;96(6):e0206521. doi: 10.1128/jvi.02065-21. Epub 2022 Feb 2.PMID: 35107369 

A humanized mouse model of chronic COVID-19.

Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, Song E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA.Nat Biotechnol. 2022 Jun;40(6):906-920. doi: 10.1038/s41587-021-01155-4. Epub 2021 Dec 17.PMID: 34921308 

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells.

Chen JS, Chow RD, Song E, Mao T, Israelow B, Kamath K, Bozekowski J, Haynes WA, Filler RB, Menasche BL, Wei J, Alfajaro MM, Song W, Peng L, Carter L, Weinstein JS, Gowthaman U, Chen S, Craft J, Shon JC, Iwasaki A, Wilen CB, Eisenbarth SC.Sci Immunol. 2022 Feb 4;7(68):eabl5652. doi: 10.1126/sciimmunol.abl5652. Epub 2022 Feb 4.PMID: 3491454

A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice.

Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M; Yale SARS-CoV-2 Genome Surveillance Initiative; Wilen CB, Landry ML, Grubaugh ND, Pyle AM, Iwasaki A.J Exp Med. 2022 Jan 3;219(1):e20211818. doi: 10.1084/jem.20211818. Epub 2021 Nov 10.PMID: 34757384

Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection.

Sharma L, Peng X, Qing H, Hilliard BK, Kim J, Swaminathan A, Tian J, Israni-Winger K, Zhang C, Habet V, Wang L, Gupta G, Tian X, Ma Y, Shin HJ, Kim SH, Kang MJ, Ishibe S, Young LH, Kotenko S, Compton S, Wilen CB, Wang A, Dela Cruz CS.J Virol. 2022 Jan 26;96(2):e0124121. doi: 10.1128/JVI.01241-21. Epub 2021 Oct 27.PMID: 34705554 

2021

Ullah, I., J. Prévost, M. S. Ladinsky, H. Stone, M. Lu, S. P. Anand, G. Beaudoin-Bussières, M. Benlarbi, S. Ding, R. Gasser, C. Fink, Y. Chen, A. Tauzin, G. Goyette, C. Bourassa, H. Medjahed, M. Mack, K. Chung, C. B. Wilen, G. A. Dekaban, J. D. Dikeakos, E. A. Bruce, D. E. Kaufmann, L. Stamatatos, A. T. McGuire, J. Richard, M. Pazgier, P. J. Bjorkman, W. Mothes, A. Finzi, P. Kumar, and P. D. Uchil. 2021. Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy. Immunity 2021. Pubmed.

Sun Y, Abriola L, Niederer RO, Pedersen SF, Alfajaro MM, Silva Monteiro V,Wilen CB, Ho YC, Gilbert WV, Surovtseva YV, Lindenbach BD, Guo JU. Restriction of SARS-CoV-2 replication by targeting programmed -1 ribosomal frameshifting. Proc Natl Acad Sci U S A 2021. Pubmed.

Hsu JC, Laurent-Rolle M, Pawlak JB,Wilen CB, Cresswell P. Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein. Proc Natl Acad Sci U S A 2021 Pubmed.

*Ravindra NG, *Alfajaro MM, *Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, *van Dijk D, *Wilen CB.. Single-cell longitudinal analysis of SARS-CoV2 infection of the human airway epithelium. PLoS Biology. 2021. Pubmed

*Flynn RA, Belk JA, Qi Y, Yasumoto Y, Wei J, Alfajaro MM, Shi Q, Mumbach MR, Limaye A, DeWeirdt PC, Schmitz CO, Parker KR, Woo E, Chang HY, Horvath TL, Carette JE, Bertozzi CR, *Wilen CB, *Satpathy AT. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell. 2021. Pubmed.

Wei J, Alfajaro MM, Hanna RE, DeWeirdt PC, Strine MS, Lu-Culligan WJ, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Gasque V, de Miguel F, Chen H, Oguntuyo K, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach B, Politi K, van Dijk D, Simon MD, Yan Q, *Doench JG, *Wilen CB. Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection. Cell. 2021. Pubmed

Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL; Yale IMPACT Research team3. Stability of SARS-CoV-2 RNA in Nonsupplemented Saliva. Emerging Infectious Diseases. 2021. Pubmed.

*Walker FC, *Hassan E, Peterson ST, Rodgers R, Schriefer LA, Thompson CE, Li Y, Kalugotla G, Blum-Johnston C, Lawrence D, McCune BT, Graziano VR, Lushniak L, Lee S, Roth AN, Karst SM, Nice TJ, Miner JJ, *Wilen CB, *Baldridge MT. Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid. PLoS Pathogens. 2021. Pubmed

Huston NC, Wan H, Strine MS, de Cesaris Araujo Tavares R, Wilen CB, Pyle AM. Comprehensive in-vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms. Molecular Cell. 2021. Pubmed

Chen JS, Alfajaro MM, Chow RD, Wei J, Filler RB, Eisenbarth SC, Wilen CB. Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection. Journal of Virology. 2021. Pubmed.

Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A.. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal of Experimental Medicine. 2021. Pubmed

Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Proc Natl Acad Sci U S A. 2021. Pubmed.

Chen JS, Chow RD, Song E, Mao T, Israelow B, Kamath K, Bozekowski J, Haynes WA, Filler RB, Menasche BL, Wei J, Alfajaro MM, Song W, Peng L, Carter L, Weinstein JS, Gowthaman U, Chen S, Craft J, Shon JC, Iwasaki A, *Wilen CB, *Eisenbarth SC. High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells. Science Immunology. 2021. Pubmed.

Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, Song E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA. 2021. A humanized mouse model of chronic COVID-19. Nature Biotechnology. 2021. Pubmed.

Ullah, I., J. Prévost, M. S. Ladinsky, H. Stone, M. Lu, S. P. Anand, G. Beaudoin-Bussières, M. Benlarbi, S. Ding, R. Gasser, C. Fink, Y. Chen, A. Tauzin, G. Goyette, C. Bourassa, H. Medjahed, M. Mack, K. Chung, C. B. Wilen, G. A. Dekaban, J. D. Dikeakos, E. A. Bruce, D. E. Kaufmann, L. Stamatatos, A. T. McGuire, J. Richard, M. Pazgier, P. J. Bjorkman, W. Mothes, A. Finzi, P. Kumar, and P. D. Uchil. 2021. Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy. Immunity 2021. Pubmed.

Sun Y, Abriola L, Niederer RO, Pedersen SF, Alfajaro MM, Silva Monteiro V,Wilen CB, Ho YC, Gilbert WV, Surovtseva YV, Lindenbach BD, Guo JU. Restriction of SARS-CoV-2 replication by targeting programmed -1 ribosomal frameshifting. Proc Natl Acad Sci U S A 2021. Pubmed.

Hsu JC, Laurent-Rolle M, Pawlak JB,Wilen CB, Cresswell P. Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein. Proc Natl Acad Sci U S A 2021 Pubmed.

*Ravindra NG, *Alfajaro MM, *Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, *van Dijk D, *Wilen CB.. Single-cell longitudinal analysis of SARS-CoV2 infection of the human airway epithelium. PLoS Biology. 2021. Pubmed

*Flynn RA, Belk JA, Qi Y, Yasumoto Y, Wei J, Alfajaro MM, Shi Q, Mumbach MR, Limaye A, DeWeirdt PC, Schmitz CO, Parker KR, Woo E, Chang HY, Horvath TL, Carette JE, Bertozzi CR, *Wilen CB, *Satpathy AT. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell. 2021. Pubmed.

Wei J, Alfajaro MM, Hanna RE, DeWeirdt PC, Strine MS, Lu-Culligan WJ, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Gasque V, de Miguel F, Chen H, Oguntuyo K, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach B, Politi K, van Dijk D, Simon MD, Yan Q, *Doench JG, *Wilen CB. Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection. Cell. 2021. Pubmed

Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL; Yale IMPACT Research team3. Stability of SARS-CoV-2 RNA in Nonsupplemented Saliva. Emerging Infectious Diseases. 2021. Pubmed.

*Walker FC, *Hassan E, Peterson ST, Rodgers R, Schriefer LA, Thompson CE, Li Y, Kalugotla G, Blum-Johnston C, Lawrence D, McCune BT, Graziano VR, Lushniak L, Lee S, Roth AN, Karst SM, Nice TJ, Miner JJ, *Wilen CB, *Baldridge MT. Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid. PLoS Pathogens. 2021. Pubmed

Huston NC, Wan H, Strine MS, de Cesaris Araujo Tavares R, Wilen CB, Pyle AM. Comprehensive in-vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms. Molecular Cell. 2021. Pubmed

Chen JS, Alfajaro MM, Chow RD, Wei J, Filler RB, Eisenbarth SC, Wilen CB. Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection. Journal of Virology. 2021. Pubmed.

Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A.. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal of Experimental Medicine. 2021. Pubmed

Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Proc Natl Acad Sci U S A. 2021. Pubmed.

2020

Stites E, Wilen CB. The Interpretation of SARS-CoV-2 Diagnostic Tests. Med. 2020. Pubmed

Tada T, Fan C, Chen JS, Kaur R, Stapleford KA, Gristick H, Dcosta BM, Wilen CB, Nimigean CM, Landau NR. An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2. Cell Reports. 2020. Pubmed.

Graziano VR, Alfajaro MM, Schmitz CO, Filler RB, Strine MS, Wei J, Hsieh LL, Baldridge MT, Nice TJ, Lee S, Orchard RC, Wilen CB. CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus. Journal of Virology. 2020. Pubmed.

Brestoff JR, Wilen CB, Moley JR, Li Y, Zou W, Malvin NP, Rowen MN, Saunders BT, Ma H, Mack MR, Hykes BL Jr, Balce DR, Orvedahl A, Williams JW, Rohatgi N, Wang X, McAllaster MR, Handley SA, Kim BS, Doench JG, Zinselmeyer BH, Diamond MS, Virgin HW, Gelman AE, Teitelbaum SL.Cell Metabolism. 2020. Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity. Pubmed

Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, *Grubaugh ND, *Wilen CB, *Wyllie AL.Simply saliva: stability of SARS-CoV-2 detection negates the need for expensive collection devices. medrxiv. 2020. Pubmed

Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Journal of Experimental Medicine. 2020 Pubmed

Farhadian S, Glick L, Vogels C, Thomas J, Chiarella J, Cassanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie A, Tucotte C, Steinle M, Pczowski P, Dela Cruz C, Wilen CB, Ko AI, Mckay S, Grurbaugh ND, Spudich S, Barakat L. Seizure as a first presentation of COVID19 associated with neuroinflammation but not with viral neuroinvasion. BMC Neurology. 2020. Pubmed

Furlong K, Biering SB, Choi J, Wilen CB, Orchard RC, Wobus CE, Nelson CA, Fremont DH, Baldridge MT, Randall G, Hwang S. CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner. Journal of Virology. 2020. Pubmed

Graziano VR, Walker FC, Kennedy EA, Wei J, Ettayebi K, Strine MS, Filler RB, Hassan E, Hsieh LL, Kim AS, Kolawole AO, Wobus CE, Lindesmith LC, Baric RS, Estes MK, Orchard RC, Baldridge MT, Wilen CB. CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus. PLoS Pathogens. 2020 Apr 6. Pubmed

Urbanek K, Sutherland DM, Orchard RC, Wilen CB, Knowlton JJ, Aravamudhan P, Taylor GM, Virgin HW, Dermody TS. Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection. Journal of Virology. 2020. Pubmed.

Wang YT, Zaitsev K, Lu Q, Li S, Schaiff WT, Kim KW, Droit L, Wilen CB, Desai C, Balce DR, Orchard RC, Orvedahl A, Park S, Kreamalmeyer D, Handley SA, Pfeifer JD, Baldridge MT, Artyomov MN, Stallings CL, Virgin HW. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nature Microbiology. 2020 Feb 5. Pubmed

Grau KR, Zhu S, Peterson ST, Helm EW, Philip D, Phillips M, Hernandez A, Turula H, Frasse P, Graziano VR, Wilen CB, Wobus CE, Baldridge MT, Karst SM. The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon. Nature Microbiology. 2020 Jan 5. Pubmed

2019

Hosmillo M#, Lu J#, McAllaster MR#, Eaglesham JB,  Wang X,  Emmott E, Domingues P,  Chaudhry Y,  Fitzmaurice TJ,  Tung MKH, Panas M, McInerney G,  Locker N, Wilen CB*, Goodfellow I*. Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation. . eLife. 2019 Aug 12. Pubmed

Sherman MB, Williams AN, Smith HQ, Nelson C, Wilen CB, Fremont DH, Virgin HW, SmithTJ. Bile salts alter the mouse norovirus capsid conformation; possible implications for cell attachment and immune evasion.Journal of Virology. 2019 Epub. Pubmed

Graziano VR, Wei J, Wilen CB. Norovirus Attachment and Entry. Viruses. 2019 May 30. Pubmed

Fritzlar S, Aktepe TE, Chao YW, Kenney ND, McAllaster MR, Wilen CB, White PA, Mackenzie JM. Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis. MBio. 2019 Jun 18;10(3). Pubmed

Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL Jr, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW. A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell Host & Microbe. 2019 May 21. Pubmed

2018

Orchard RC, Wilen CB, Virgin HW. Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection. Nature Microbiology. 2018; 3(10):1109-1114. Pubmed

Nelson CA*, Wilen CB*, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH. Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(39):E9201-E9210. Pubmed

Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS. Interactionbetween smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease. Journal of Clinical Investigation. 2018. Pubmed

Wilen CB, Lee S, Hsieh LY, Orchard RC, Desai C, Hykes BL, McAllaster M, Balce D, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang Y, MacDuff D, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PA, Handley SA, van lookeren Campagne M, Baldridge MT, Virgin HW. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science.(2018) Apr 13. Pubmed

McMullen AR, Wilen CB, Burnham CAD. Epidemiology of Blood Stream Infections in the Dark Art of Blood Culture.  Dunne M and Burnham CAD, Editors. ASM press. (2018). Link

2017

Lee S, Wilen CB, Orvedahl A, McCune BT, Kim KW, Orchard RC, Peterson ST, Nice TJ, Baldridge MT, Virgin HW. Norovirus cell tropism is determined by combinatorial action of a viral non-structural protein and host cytokine. Cell Host & Microbe. (2017) Oct 11. Pubmed

Biering SB,Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, and Hwang S. Viral replication complexes are targeted by LC3-guided interferon-inducible GTPases. Cell Host & Microbe. (2017) Jul 12;22(1):74-85. Pubmed

Wilen CB, Booth GS, Grossman BJ, Lane WJ, Szlarski PC, Jackups R. Using direct antiglobulin test results to reduce unnecessary cold agglutinin testing. Transfusion.(2017) Mar 7; 57(6): 1480-4. Pubmed

2016

Orchard RC*, Wilen CB*, Doench JG, Baldridge MT, McCune BT, Lee YJ, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, and Virgin HW. Discovery of a proteinaceous cellular receptor for a norovirus. Science. (2016): 353(6302):933-6. Pubmed

O’Brien M, Manches O, Wilen CB, Wu V, Sunseri N, Bhardwaj N. CD4 receptor is key determinant of divergent HIV-1 sensing by plasmacytoid dendritic cells (2016) PLoSPathogens. (2016) Apr 15;12(4)e1005553. Pubmed

Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova, Wilen CB, Orchard RC, Virgin HW, Listgarten J, and Root DE.  Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nature Biotechnology. (2016) 34(2):184-91. Pubmed

Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Levano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kown DS, and Virgin HW. Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-associated Acquired Immunodeficiency Syndrome. Cell Host & Microbe(2016) 19(3): 311-22. Pubmed

Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DG, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon ACM, Zhang H, Randolph GJ, Artyomov MN, and Virgin HW. Homeostatic control of innate immune lung inflammation by Vici syndrome gene Epg5and additional autophagy genes promotes influenza virus pathogenesis.  Cell Host & Microbe(2016) 19(1):102-13. Pubmed

2015

Gonzalez MD*, Wilen CB*, and Burnham CAD. Markers of intestinal inflammation for the diagnosis of infectious gastroenteritis. (2015) Clin Lab Med. 34(2): 333-44. Pubmed

Wilen CB, McMullen AR, and Burnham CAD. Comparison of sample preparation methods, instrumentation platforms, and contemporary commercial databases for identification of clinically relevant mycobacteria by matrix-assisted laser desorption ionization-time of flight mass spectrometry. (2015) J Clin Micro. 53(7): 2308-15. Pubmed

Wilen CB, Szymanski JJ, Hung S, Rajan A, Lavigne PM, Char DM, Geltman EM, and Scott MG. The impact on patient management and outcome of switching between two contemporary sensitive cardiac troponin assays. (2015) Clin Chem. 61(6):870-6. Pubmed

Wilen CB, Monaco CM, Hoppe-Bauer J, Jackups R, Bucelli RC, Burnham CAD.  Criteria to reduce unnecessary testing for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and enterovirus in cerebrospinal fluid samples from adults. (2015) J Clin Micro.52(3): 887-95.  Pubmed

2014

Wilen CB, Orner C, Brown SM. Sustaining Point of Care Testing in a Resource-Limited Environment: Experiences in Hispaniola, in Global Point-of-Care Strategies for Disasters, Complex Emergencies, and Public Health Crises: Enhancing Standards of Care at the Site of Need.Kost GJ and Curtis CM, editors. 2014, AACC Press: Washington, DC.

Petersen J*, Drake MJ*, Bruce EA*, Riblett AM, Didigu CA, Wilen CB, Malani N, Male F, Lee FH, Bushman FD, Cherry S, Doms RW, Bates P, Briley K Jr. The major cellular sterol regulatory pathway is required for andes virus infection. (2014) PLoS Pathogens 10(2):e1003911. Pubmed

Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW. Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. (2014) Blood123(1): 61-9. Pubmed

2013

Parrish NF, Gao F, Li H, Giorgi EE, Barbian HJ, Parrish EH, Zajic L, Iyer SS, Decker JM, Kumar A, Hora B, Berg A, Cai F, Hopper J, Denny TN, Ding H, Ochsenbauer C, Kappes JC, Galimidi RP, West AP Jr, Bjorkman PJ, Wilen CB, Doms RW, O'Brien M, Bhardwaj N, Borrow P, Haynes BF, Muldoon M, Theiler JP, Korber B, Shaw GM, Hahn BH. Phenotypic properties of transmitted founder HIV-1.  (2013) Proc Natl Aca Sci110(17):6626-33.  Pubmed

Parker ZF*, Iyer SS*, Wilen CB, Parrish NF, Chikere KC, Lee F, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, and Doms RW. Transmitted/Founder and Chronic HIV-1 Envelope Proteins are Distinguished by Differential Utilization of CCR5. (2013) J Virol 87(5):2401-11. Pubmed

2012

Parrish NF*, Wilen CB*, Banks L, Iyer S, Pfaff JM, Salazar-Gonzalez JF, Salazar MG, Decker JM, Parrish EH, Berg A, Hopper J, Kumar A, Mahlokozera T, Yuan S, Coleman C, Vermeulen M, Ochsenbauer C, Tilton JC, Permar SR, Kappes JC, Betts MR, Busch MP, Gao F, Montefiori D, Haynes BF, Shaw GM, Hahn BH, Doms RW.  Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.  (2012) PLoS Pathogens. 8(5):e1002686. Pubmed

Wilen CB, Tilton JC, Doms RW.  HIV: cell binding and entry, in Human Immunodeficiency Virus. FD Bushman, G Nabel, and R Swanstrom, Editors. 2012, Cold Spring Harbor: Cold Spring Laboratory Press:  Cold Spring Harbor, NY. Pubmed

Wilen CB, Tilton JC, and Doms RW.  Molecular mechanisms of HIV entry, in Viral Molecular Machines, M. Rossman and V. Rao, Editors. 2012, Springer-Verlag: New York, NY. Pubmed

2011

Jiang C*, Parrish N*, Wilen CB*, Li H*, Chen Y, Pavlicek JW, Berg A, Tomaras G, Tilton JC, Decker JM, Haynes BF, Shaw GM, Doms RW, Hahn BH, Gao F. Primary infection by a human immunodeficiency virus with atypical coreceptor tropism. (2011) J Virol 85(20):10669-81. Pubmed

Wilen CB*, Parrish N*, Pfaff JM, Decker JM, Henning EA, Haynes BF, Tilton JC, Shaw GM, Hahn BH, Doms RW. Phenotypic comparison of clade B transmitted/founder and chronic HIV-1 Envs. (2011) J Virol 85(17):8514-27.Pubmed

Wilen CB, Wang J, Tilton JC, Miller JC, Kim KA, Rebar EJ, Sherrill-Mix SA, Patro SC, Secreto AJ, Jordan APO, Lee G, Kahn J, Aye PP, Bunnell BA, Lackner AA, Hoxie JA, Danet-Desnoyers GA, Bushman FD, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW. Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc finger nucleases. (2011) Plos Pathogens. 7(4):e1002020. Pubmed

2010

Tilton, JC, Wilen CB, Didigu C, Sinha R, Harrison J, Agrawal-Gamse C, Henning E, Bushman FD, Deeks SD, Doms RW.  A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5. (2010) J Virol 84(20):10863-76.Pubmed

Leung W, Shaffer CD, Cordonnier T, Wong J, Itano MS, Slawson Tempel EE, Kellmann E, Desruisseau DM, Cain C, Carrasquillo R, Chusak TM, Falkowska K, Grim KD, Guan R, Honeybourne J, Khan S, Lo L, McGaha R, Plunkett J, Richner JM, Richt R, Sabin L, Shah A, Sharma A, Singhal S, Song F, Swope C, Wilen CB, Buhler J, Mardis ER, Elgin SC. Evolution of a distinct genomic domain in Drosophila: comparative analysis of the dot chromosome in Drosophila melanogaster and Drosophila virilis. (2010) Genetics 185(4):1519-34. Pubmed

Pfaff JM, Wilen CB, Harrison JE, Demarest JF, Lee B, Doms RW, Tilton JC.  HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells. (2010) J Virol. 84(13):6505-14. 

*These authors contributed equally